![]() ( f) Negative correlation between HAM-D and mReHo in right superior temporal gyrus and right angular gyyrus. ( e) Positive correlation between HAM-D and mReHo in left supplementary motor area. ( d) Negative correlation between HAM-D and mfALFF in left middle temporal gyrus. ![]() ( c) Negative correlation between HAM-D and mfALFF in right angular gyrus. ( b) Negative correlation between HAM-D and mfALFF in left precentral gyrus, left middle frontal gyrus. ( a) Positive correlation between HAM-D and mfALFF in left inferior triangular frontal gyrus. Graph theoretical analysis network-based statistical analysis resting-state functional connectivity suicide attempt. We concluded that the brain function of major depressive disorders with and without suicide attempts changed compared with healthy participants. Graph theoretical analysis (GTA) and network-based statistical (NBS) analyses revealed different topological organization as well as slightly better global integration and worse local segregation of the brain network (i.e., more like a random network) in depressed participants compared with healthy participants. We also found that some brain areas correlated with the Hamilton Depression Rating Scale (HAM-D), anxiety, and depression scores, especially in the frontal and temporal lobes. In the voxel-based analysis, our results showed differential activation and regional homogeneity of the temporal lobe and several brain regions in the SA compared with the NS and HC. In seed-based correlation analysis, we found altered functional connectivity in some brain regions of the SA compared with the NS or HC, especially in the hippocampus and thalamus. ![]() All participants were scanned using a 3 T MRI imaging system to obtain resting-state functional images. ![]() Our study recruited 109 participants who were assigned to three groups: 33 depressed patients with suicide attempt (SA), 32 depressed patients without suicide attempt (NS), and 44 healthy controls (HC). The association between depression severity and aspects of the brain imaging was also discussed. Our study aimed to clarify the neuroimaging correlates of suicide attempt by comparing differences in functional magnetic resonance imaging (fMRI) among depressed suicide attempters, depressed patients without suicide attempt history, and healthy controls through comprehensive and novel fMRI analyses and methods in the same study population. ![]()
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